PhD_opening_bioNMR_Schanda

Three PhD positions in Biomolecular NMR are open in the Schanda group atthe Institute of Science and Technology Austria (ISTA)Use solution-and solid-state NMR to address chaperone function and proteintranslocationWe study howchaperones assist other proteins to fold, and how a network of chaperones, co-chaperones and receptor domains assists protein import into mitochondria. You will decipher e.g.the functional mechanisms by which the very dynamic protein-import machinery is able toefficiently insert proteins into mitochondria-or to clear up proteins in cases where the machinerygets clogged. The complexes we study comprise soluble chaperones, membrane-embeddedinsertases, as well as the to-be-imported proteins; we have developed approaches to generatesuch complexes efficiently. You will combine solution-and magic-angle spinning (MAS) NMRwith biochemistry and biophysics, as well as cellular experiments, together with our international collaborators.

Develop and apply MAS NMR to study how dynamics underlies protein function, and howevolution shaped allosteryProtein dynamics are essential for their function. We use MAS NMR to probe the dynamics orlarge enzymatic complexes, often hundreds of kilodaltons in size. By determining motions atresidue-specific resolution, we probe, for example, the presence of transient, low-populatedstates and their relevance for function. In the ongoing projects we address how evolution hasshaped protein dynamics and how processes such as allosteric regulation are rooted in dynamiccoupling of different parts of an enzyme.

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